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Is it better to take spironolactone in the morning or at night? Spironolactone is commonly prescribed just once daily and you can generally take the dose at a time to suit you. However, diuretics are best taken no later than mid-afternoon. However, if it is after 6 pm in the evening, skip the missed dose and continue as usual the next day.
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How long does it take for spironolactone to get out of your system? It may take about 2 weeks or longer before the full effect of spironolactone occurs. Continue to take spironolactone even if you feel well. Do not stop taking spironolactone without talking to your doctor.
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